It happened at 8:00 a.m. Thursday at Hook and Industrial Roads in Sharon Hill.
Images from Chopper 6 HD over the scene showed a dark colored pickup truck with heavy front-end damage and a large utility truck nearby.
Sand covered the road near the pickup truck, suggesting fuel may have spilled following the collision.
There was no immediate word on the driver's condition or if the other driver suffered any injuries.
An investigation is underway.