Jonas Valanciunas had 12 points and matched his career high with 13 rebounds, Amir Johnson had 17 points and 10 rebounds and Greivis Vasquez scored 12 in his first game with Toronto as the Raptors won for just the second time in eight games. Kyle Lowry had a season-high 11 assists for Toronto.
Tony Wroten scored 23 points, Evan Turner had 21 and Thaddeus Young 18 for the 76ers, who lost for the ninth time in 10 games. Spencer Hawes had 15 points and James Anderson scored 13 for the Sixers, who have gone 4-17 since starting the season 3-0.
The 76ers, who matched a season worst with 26 turnovers in Wednesday's loss at Minnesota, gave the ball away 17 times on Friday, leading to 19 Raptors points.
Consecutive baskets by Young brought Philadelphia within five at 87-82 with 8:22 left in the fourth, but Toronto responded with three straight 3-pointers, two of them from Vasquez, taking a 96-82 lead with 7:11 left.
Philadelphia didn't go quietly, however, and a running layup by Wroten cut it to 100-98 with 1:56 remaining. Ross answered with a 3 and DeRozan made one of two from the line, then hit a jumper, putting Toronto up 106-98 with 40 seconds left.
Ross had two dunks and a pair of 3-pointers in the first, scoring 12 points in the quarter as the Raptors built a 36-21 lead after one.
Philadelphia closed the gap with a 10-0 run to start the second, including six points from Anderson. The Raptors, who made only six of 16 field goal attempts in the quarter, struggled to hold on to the lead but remained in front thanks to eight points from DeRozan. Toronto led 56-48 at halftime.
The Raptors made eight turnovers in the second, struggling as they integrated newcomers Vasquez, Patrick Patterson and John Salmons into the lineup. All three were acquired from Sacramento on Monday in the trade that sent Rudy Gay to the Kings.
Even with their starters back in, Toronto struggled to regain control in the third. DeRozan scored nine points, while Ross and Valanciunas each had six, but Turner had nine points and Hawes eight for Philadelphia, which trailed 83-76 heading into the fourth.
NOTES: Sixers G Michael Carter-Williams missed his fifth straight game with a sore right knee. ... Toronto F Chuck Hayes, also acquired from Sacramento, will not be cleared to play until he undergoes baseline cardiac testing. Hayes, who displayed an abnormality during heart tests in 2011, is unlikely to suit up until next Wednesday's game against Charlotte. ... Tyler Hansbrough returned for the Raptors after missing the previous two games with a sore left shoulder. ... The game went ahead despite a strike by some 600 catering, housekeeping and stadium conversion staff that began earlier Friday. Striking staff picketed outside the arena as fans arrived.