Clinton is scheduled to speak at the university's Liacouras Center on April 10.
A question-and-answer session moderated by former Pennsylvania Gov. Ed Rendell is to follow.
The event is hosted by the Temple University Law Foundation, a group founded in 1959 to raise money for Temple's Beasley School of Law.
The foundation said Clinton's remarks will launch a new annual guest lecture series that aims to raise funds for student scholarships and loan repayment assistance programs.