Officials responded to the motel located at 500 North Albany Avenue just before 10:00 a.m. Sunday.
Heavy fire was reported on the second floor, where the fire originated.
Fire crews helped rescue people who were still inside the motel.
At least 10 rooms were damaged, including three that were completely destroyed.
The fire was placed under control at 10:20 a.m.
There is no word on a cause at this time.