The incident happened just past 11:30 p.m. inside a house located on the 5000 block of F Street.
A 28-year-old man was shot in the eye and pronounced dead a short time later, police say.
The second male, a 25-year-old was shot in the leg. He was taken to the hospital and is listed in critical condition.
Police say they confiscated heroin packets from the room.
There are no arrests, but officers suspect the gunman knew his victims.