The agency says a daily aspirin has been proven to prevent attacks for people who've already had one.
But the FA said there's no evidence it can ward off a first one. And it can cause bleeding in the stomach or the brain.
Many doctors, and even the American Heart Association back aspirin for high-risk patients to prevent first-time attacks.
But everyone is different, so this is something you should ask your doctor- what's best for you.
On Friday, the FDA rejected Bayer Healthcare's decade-old petition requesting approval of a primary prevention indication.