At least a dozen shell casings littered the area of 13th and Claymont streets around 10 p.m. Wednesday.
A 25-year-old woman was shot in the chest. She was taken to Christiana Hospital in critical condition.
Police say her 26-year-old brother went to Wilmington Hospital in a private vehicle and is in stable condition with a gunshot wound to his shoulder and jaw.
Some parked cars were also hit in the shooting.
Authorities describe the suspect as a black male last seen wearing a green Philadelphia Eagles cap, camouflage jacket, black sweatshirt, dark pants with a white strip on the sides and black sneakers.
Anyone with information should contact Detective Joran Merced at (302) 576-3637.
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