The singer's manager, Tom Vitorino, confirmed the death to The Associated Press early Friday morning. Vitorino said he learned of Weiland's death from his tour manager. He did not provide further details but referenced a statement on Weiland's Facebook page.
The statement said Weiland, who was dogged by substance abuse problems throughout his career, passed away in his sleep while on a tour stop in Bloomington, Minnesota. The local coroner confirmed the death Friday but didn't cite a cause.
Weiland's current band, Scott Weiland & the Wildabouts, had been scheduled to play a show in nearby Medina, Minnesota, according to a local venue's website. The website showed the event was canceled but didn't give a reason.
Weiland's wife, Jamie Weiland, also confirmed his death to the Los Angeles Times.
"I can't deal with this right now," she said, sobbing. "It's true."
The singer rose to fame as the frontman of the Grammy Award-winning Stone Temple Pilots, whose hits include "Interstate Love Song," ''Plush," and "Vasoline."
The band broke up in 2003, and Weiland went on to front Velvet Revolver, the super group that featured former members of Guns N' Roses, including guitarist Slash and bassist Duff McKagan. Among that group's hits was "Fall to Pieces."
The Stone Temple Pilots eventually reunited in 2008.
"The story's not finished," Weiland told the AP at the time. "There's more to be revealed and more to be told."
But the group split again in 2013.
Weiland had a long string of drug- and alcohol-related arrests and stints in rehab. In 1995, he was arrested after deputies found him carrying crack and heroin. He pleaded guilty to felony heroin possession in 1998. And his arrests for drug possession and stints in rehab led the Stone Temple Pilots to cancel tour dates and contributed to their 2003 breakup.
The Hennepin County medical examiner confirmed Weiland's death in a news release Friday but didn't list a cause. Carolyn Marinan, a county spokeswoman, said she had no information on when that would be announced.
This story has been corrected to show that Jamie Weiland commented to the Los Angeles Times, not the Los Angeles Tribune.