CHOP announced Friday that it has notified the Centers for Disease Control about three patients who have acute muscle weakness.
Hospitals across the country have reported similar symptoms.
Officials believe the cases here could be connected to the current outbreak of enterovirus D68 respiratory disease.
The patients at CHOP have not yet tested positive for the disease, but further testing is underway.
Dr. Brenda Banwell said what the hospital is reporting to the CDC is troubling.
"We might we see three to eight in 12 months. To see three in a short time is unusual and that's what other centers are seeing as well," Banwell said.
Health officials say two dozen enterovirus patients in seven states have reported muscle weakness, including the inability to move their limbs.
Some centers are also seeing MRI images that show inflammation in the gray matter of the spinal cord. That's the area that control movement.
It's not yet known if enterovirus D-68 to blame for the muscle weakness. It is also not known if the weakness will be permanent.
CHOP is reminding parents and guardians that any signs of respiratory illness accompanied by breathing difficulty or muscle weakness should be reported to the child's doctor immediately.
Enterovirus is now confirmed in 43 states plus the District of Columbia.
LINK: List of symptoms of enterovirus from the CDC