Police said they responded to a fight in progress Saturday around 1 a.m. near East 169th Street and Prospect Avenue in the Bronx.
Nearby, they found 40-year-old Troy Scott, from Birmingham, unconscious and unresponsive. He was transported to Lincoln Hospital where he was pronounced deceased.
Police said the victim was involved in a verbal dispute with the attacker before he was punched. Scott then fell, hit his head and died, police said.
The medical examiner has yet to determine the official cause of death.
An investigation is ongoing. So far, no arrests have been made.
A person of interest is being sought out by police. He's described as a Hispanic man who's approximately 5'7" tall. He was last seen fleeing in a red vehicle southbound on Prospect Avenue.
Scott's family said he flew to New York on Friday for his sister's baby shower, and he was scheduled to return home Monday.
"If he knew who my son was, he never would have done what he did," Stedroy Phillips, Scott's father, told WABC-TV. "My son had a heart of gold."