Murray was ruled out because of a hamstring injury, Action News sports anchor Jeff Skversky reports.
Eagles RB Ryan Mathews will start for Murray. Mathews has rushed for over 1,000 yards twice but played only 8 games last year.
Eagles RB Ryan Mathews starts for DeMarco Murray. Mathews has rushed for over 1,000 yds twice but played only 8 games last year— Jeff Skversky (@JeffSkversky) September 27, 2015
Murray, the NFL's rushing leader last season with 1,845 yards, has been held to just 11 yards on 21 attempts this season.
Playing behind a rebuilt offensive line, Murray has been constantly hit behind the line of scrimmage. He was visibly upset during last week's game against the Dallas Cowboys - his former team - in which he gained only 2 yards on 13 carries.
WR Josh Huff is also inactive.
Eagles inactives: QB Lewis, WR Huff, RB Murray, LB Alonso, DE Thornton, LB Kendricks, DE Hart. pic.twitter.com/00HOC4QYOR— Jeff Skversky (@JeffSkversky) September 27, 2015