The first burglary happened just after midnight back on March 25 at the Philly Pharmacy on the 9400 block of Roosevelt Boulevard in Northeast Philadelphia.
The same thieves struck again just after 4 a.m. at the nearby Academy Pharmacy.
Police believe the suspects are also responsible for forcing open several ATM machines in May and June in West and Southwest Philadelphia.
Click here to watch the surveillance video
In August, the burglars targeted the Amigo Pharmacy on the 3000 block of Kensington Avenue, stealing a large quantity of drugs and other items valued at $11,000.
The latest incident occurred on September 14 at the Broad and Grange Pharmacy at 5751 North Broad Street in North Philadelphia.
This time police say the suspects forced open a rear door, cut the wire to the alarm system and stole medications from storage units.
Anyone with information on any of these crimes should call police at 215.686.TIPS (8477) or text a tip to PPD TIP (773847).
You can also submit an anonymous tip online at PhillyPolice.com.