Eleven of the 15 suspects were arrested early Friday at various locations and were awaiting arraignment, officials said.
Four remain at large.
Pennsylvania Attorney General Kathleen Kane said the arrests came after a nearly year-long investigation dubbed Operation Bennett Trifecta, which began early in 2015.
The operation culminated in a raid on several homes in Chester and surrounding communities in late 2015, Kane said, which resulted in the seizure of two kilograms of cocaine, a bullet proof vest, ammunition, $40,000 in cash, and various associated paraphernalia.
Investigators estimate the ring sold $5-15 million worth of cocaine over the course of a year.
This is the fifth major drug bust announced by the AG's office in the past month, resulting in charges for 153 people across the state.
Also Friday, investigators announced the arrests of 33 people in an investigation targeting a heroin trafficking ring in Johnstown, Pa.
A sweep just announced on Thursday in Blair County, Pa. netted 35 arrests, including a man from Philadelphia.
And just one day before, the AG's office announced 43 arrests in a sweep targeting a ring with ties to Detroit.
In late March, another Philadelphia man was caught up in a sweep that ended with 27 arrests in Clearfield County.
In the Chester case, the following people have been charged with offenses including drug possession and possession with intent to deliver narcotics:
-David Toney, 44, Delaware
-James Townsend, 37, Chester
-Cheron Jackson, 34, Chester
-Darrell Burton, 41, Chester
-Lafenus Burton, 43, Chester
-Byron Parker, 40, Chester
-Chris Jones, 43, Chester
-Anthony Reaves, 36, Chester
-Louis Freeman, 45, Chester
-Darryl Bannister, 38, Chester
-Tyrone Pringle , 28, Chester
-Dron Adams, 22, Chester
-Kemp Hill, 27, Chester
-Ronald South, 40, Chester
-Wilbert Jones, 61, Chester
Investigators from the Pennsylvania State Police, Bureau of Criminal Investigation, Drug Law Enforcement Division were assisted by troopers from the Pennsylvania State Police Troop K, Vice Unit and the Bureau of Emergency and Special Operations, the Chester City Police Department, Delaware County District Attorney's Office, and the Delaware State Police.
The case is being prosecuted by the Pennsylvania Attorney General's Office.