The crash happened before 7 a.m. at the intersection of Basin Road and Washington Lane.
The accident involved a sedan and an SUV.
Police say a 17-year-old female was driving the SUV, and a 19-year-old male driver was in the sedan.
The impact of the crash caused the sedan to roll into a utility pole.
Both victims were treated at the scene, and then taken to Christiana Hospital for treatment.
The female suffered a possible head injury. She is in serious, but stable condition.
The male suffered bruises and abrasions. He is in stable condition.
The crash remains under investigation.