A three-day operation was conducted late last week, the Philadelphia Police Department announced on Wednesday.
Police say most of the arrests were for drug warrants and as part of drug investigations. Additionally, a number of people were arrested on outstanding warrants.
In all, 64 people were arrested, including one juvenile.
Police also seized multiple guns, 15 vehicles and more than $6,000 in cash.
"I hope it says to the community that we're there to support them. We're not going to abandon them, this is something we're going to have to work on together as a team," said Capt. Altovise Love-Craighead, head of the 16th District. "We're going to push forward and make sure we get the bad guys off the street."
VIDEO: Full news conference with Philadelphia Police
Police said they organized the operation in three parts:
Day 1 (10/26) was focused on serving warrants and targeting specific drug locations.
Day 2 (10/27) was an "attack on open-air drug markets," police said. It was conducted by Narcotic Strike Force and Narcotics Enforcement Teams.
Day 3 (10/28) was focused saturating the communities with patrols to discourage crime, police said, while also engaging with people in the communities.
"The impact of this is important because not only does it show the community that they can be friendly with the police, but also shows them they can come out and take part in some of the activities we have and not be afraid of the drug dealers out there," said Love-Craighead.
Police say they also confiscated drugs with a combined street value of nearly $30,000.