The incident happened on January 20 around 7:30 p.m. inside the Pathmark pharmacy on the 3300 block of Aramingo Avenue.
Police say the suspect walked into the supermarket wearing a rubber mask and headed towards the pharmacy.
VIDEO: Click here to watch the surveillance video
He flashed a handgun before handing over a plastic bag to an employee behind the counter and demanding it be filled with narcotics.
The robber then fled the supermarket in a dark colored 4-door vehicle with oversized wheels and was last seen driving towards Aramingo Avenue.
Police describe the suspect as a white male, 6'1" tall and heavy set. He was wearing a light brown/tan rubber mask, Philadelphia Eagles cap with ear flaps, green jacket with a stripe across the chest, blue jeans and black sneakers.
Anyone with information on this robbery is asked to contact Philadelphia police at 215.686.TIPS (8477) or text a tip to PPD TIP (773847).
Tips will remain confidential.