It happened at 2:30 a.m. inside the Dauphin Discount store on the 2800 block of West Dauphin Street.
Investigators say the thief broke into the store through a rear wall.
Once inside, he stole various items before escaping in an unknown direction.
Police describe the suspect as a black male, 35-45 years-old with a beard. He was wearing a dark colored hooded jacket and a dark colored baseball cap.
Anyone with information should contact police at 215.686.TIPS (8477) or text a tip to PPD TIP (773847).
VIDEO: Click here to see the surveillance video