It happened inside the Sun Ray Pharmacy located on the 1500 block of North Broad Street.
Police say the suspect walked into the pharmacy at 4:40 p.m. and demanded money from the cash register or he would shoot everyone in the store.
He got away with $200 in cash before fleeing into a waiting taxi.
Click here to watch the surveillance video
Police describe the suspect as a black male, 25 to 35-years-old, 5'9" tall with a thin build, goatee and dark complexion. He was wearing a black t-shirt, blue jeans and a dark colored baseball cap.
Anyone with information should call police at 215.686.TIPS (8477) or text a tip to PPD TIP (773847).
You can also submit an anonymous tip online at PhillyPolice.com.