It happened early Thursday morning at Luna Cafe located on the 300 block of West Market Street.
Police say the man broke into the restaurant shortly after 1 a.m. by shattering a rear window.
Once inside, surveillance cameras captured the burglar stealing an unknown amount of cash from the registers before fleeing the scene.
The suspect is described as a black male, middle aged and average height and build. He had a long beard and was wearing a baseball cap, glasses and was carrying a backpack.
Anyone with information should call Central Detectives at 215-686-3093.
Click here to watch the surveillance video