The wreck happened around 2:30 a.m. Saturday along Kelly Drive in Fairmount Park.
PHOTOS: Car submerged in Schuylkill River
Police say the car was driven off the Roosevelt Boulevard, crossed over Ridge Avenue and then crossed Kelly Drive before hitting a curb. The impact sent the vehicle airborne.
The car landed in 6 feet of water about 40 feet away from shore.
Rescue crews eventually pulled the body of a 26-year-old man from the vehicle. He was pronounced dead on the scene.
The accident remains under investigation.
VIDEO: Car submerged in Schuylkill River