Firefighters responded to the home at 1:50 a.m. Wednesday in the unit block of Clay Hill Lane.
A 2-year-old child was airlifted to St. Christopher's Hospital for Children in Philadelphia.
A man and woman, believed to be in their 20s, were airlifted to Temple University Hospital.
All were being treated for injuries including smoke inhalation.
There was no official word on their conditions, though fire officials tell Action News all three were alert and speaking as they were being transported from the scene.
Stay with Action News and 6abc.com for more information as it becomes available.