The accident happened at 1:36 p.m. Sunday at the intersection of South Mill and New Edinburg roads in West Windsor Township, New Jersey.
Police said a vehicle traveling northbound exited the roadway, striking a tree.
The driver, 74-year-old Timothy R. Ignas, and 65-year-old passenger, Nicoleta Oliver, both of Henderson, Nevada, were pronounced dead at the scene.
A second passenger, 73-year-old Lorraine M. Ignas, also of Henderson, Nevada, was rushed to Capital Health Regional Medical Center for unknown injuries. Her condition is unknown.
The crash is under investigation.
Anyone with information about the incident is asked to contact police at 609-799-1222.