It happened after 5 a.m. Thursday in the eastbound lanes approaching I-95.
Video from Chopper 6 HD showed a car carrier truck which appeared to have jackknifed across both eastbound lanes of Route 322 and struck the concrete median, partially breaking through it.
A dark colored SUV appeared to be crushed between the cab and trailer portion of the car carrier.
Action News is told one person was killed. No further details have been released.