The call went out at 9:17 a.m. Monday for a fire at Chalfont Hardware in the 200 block of East Butler Avenue.
Initial reports indicated the fire broke out on the second floor of the building and spread to the roof.
Video from Chopper 6 HD showed multiple police and firefighting units on the scene.
There were no immediate reports of injuries.
Fire investigators are working to determine what sparked the blaze.