It happened around 7:30 p.m. Wednesday in the northbound lanes of I-95.
The video shows two cars stopped at a toll booth when the striking vehicle comes into the frame at a high rate of speed.
The car then slams into another vehicle, which then slams into a third.
Another vehicle in an adjacent lane was hit by flying debris.
PHOTOS: Scene of Delaware toll plaza crash
The driver of the striking vehicle, 31-year-old Matt Rude of McLean, Virginia, has been charged with DUI.
Four people were taken to the hospital with injuries.
Two toll booths were also damaged.