It happened around 10:27 a.m. in the 1500 block of Vine Street.
According to police, the child and his 36-year-old mother were crossing Vine Street when they were hit.
Both were taken to the hospital. The boy was pronounced dead around 11:45 a.m.
The striking vehicle remained at the scene, police said.
Witness Brad Konell told Action News he heard a noise and turned around to see the stroller on its side with the child still strapped in.
He said he heard the child crying, which he thought was a good sign. He got the bad news a short time later.
"A bike cop told me the baby passed away," Konell said.
There was no immediate word on if the pickup truck driver would be charged.
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