Officials say the incident happened just after 5 p.m. in the area of Lackawanna and Schuylkill avenues for a shooting victim.
When police arrived on the scene, they located a 19-year-old shooting victim with fatal injuries.
Officials say police were directed to a vehicle that fled the scene.
Authorities were then able to locate and stop that vehicle on the 700 block of Schuylkill Avenue.
The 18-year-old driver, identified as Wilson Ventura-Cruz, was arrested and taken into custody.
Ventura-Cruz was charged with first-degree murder and related charges.
The Reading Police Department Criminal Investigations Division is investigating this homicide.
Anyone with information is asked to contact 610-655-6116.
Information can also be provided anonymously by calling Crime Alert Berks County's anonymous tip line at 1-(877)-373-9913.