The shooting happened just before 2:30 a.m. on the 2400 block of South 61st Street.
According to police, the gunman approached the woman and started firing.
Authorities say she was shot multiple times in the arm, chest and stomach.
Bullets were also fired into the home, but police said the two people inside, including a teen, were not injured.
There was no immediate word on a motive in this shooting.
Anyone with information is asked to call police.