2024 NFL Week 2: Betting odds and lines for every game

ByESPN ESPN logo
Friday, September 13, 2024

Week 2 of the NFL schedule kicked off Thursday with an AFC East matchup between the underdogBuffalo Billswho upset slight favorites Miami Dolphins31-10. It will conclude on Monday Night Football when Jalen Hurts and the Philadelphia Eagles play their home -- and North American -- opener against the Atlanta Falcons.

The Las Vegas Raiders opened as the biggest underdogs of the week and that line has continued to move their road date with the Baltimore Ravens, while the biggest total on the slate belongs to the Tampa Bay Buccaneers and Detroit Lions for their Sunday afternoon game in Detroit. C.J. Stroud and theHouston Texansare giving up 6.5 points to Caleb Williams and the Chicago Bears for Sunday's night game.

Here's a look at all the Week 2 games. Football Power Index (FPI) by ESPN Sports Analytics. Odds current as of publication time. For most current odds go to ESPN BET

2024 NFL Week 2 spreads, money line and totals

Sunday 1:00 PM ET, CBS

Money Line: 49ers (-230) ; Vikings (+195)

Total: 46.5; Opened: 46.5

FPI favorite: 49ers by 5

Sunday 1:00 PM ET, CBS

Line movement: opened Chargers -3

Money Line: Chargers (-230) ; Panthers (+195)

Total: 39.5; Opened: 42

FPI favorite: Chargers by 7

Sunday 1:00 PM ET, FOX

Money Line: Colts (-150) ; Packers (+130)

Total: 40.5; Opened: 47.5

FPI favorite: Colts by 1.8

Sunday 1:00 PM ET, FOX

Money Line: Giants (+105) ; Commanders (-125)

Total: 43.5; Opened: 42.5

FPI favorite: Commanders by 4.3

Sunday 1:00 PM ET, FOX

Money Line: Saints (+220) ; Cowboys (-270)

Total: 46.5; Opened: 44.5

FPI favorite: Cowboys by 4.2

Sunday 1:00 PM ET, CBS

Money Line: Browns (+140) ; Jaguars (-165)

Total: 41.5; Opened: 44.5

FPI favorite: Jaguars by 2.4

Sunday 1:00 PM ET, CBS

Money Line: Jets (-195) ; Titans (+165)

Total: 41.5; Opened: 44

FPI favorite: Jets by 3

Sunday 1:00 PM ET, FOX

Money Line: Buccaneers (+280) ; Lions (-350)

Total: 51.5; Opened: 48.5

FPI favorite: Lions by 5.9

Sunday 1:00 PM ET, CBS

Money Line: Raiders (+340) ; Ravens (-425)

Total: 41.5; Opened: 44

FPI favorite: Ravens by 8.9

Sunday 1:00 PM ET, FOX

Money Line: Seahawks (-185) ; Patriots (+155)

Total: 37.5; Opened: 42.5

FPI favorite: Seahawks by 2.4

Sunday 4:05 PM ET, FOX

Money Line: Rams (+EVEN) ; Cardinals (-120)

Total: 47.5; Opened: 47.5

FPI favorite: Rams by 1.1

Sunday 4:25 PM ET, CBS

Line movement: opened Chiefs -3.5

Money Line: Bengals (+210) ; Chiefs (-250)

Total: 48.5; Opened: 48.5

FPI favorite: Chiefs by 6.3

Sunday 4:25 PM ET, CBS

Line movement: opened Broncos -0.5

Money Line: Steelers (-140) ; Broncos (+120)

Total: 36.5; Opened: 40.5

FPI favorite: Steelers by 2.9

Sunday 8:20 PM ET, NBC, Peacock

Money Line: Bears (+240) ; Texans (-290)

Total: 45.5; Opened: 46.5

FPI favorite: Texans by 5.9

Monday 8:15 PM ET, ESPN

Line movement: opened Eagles -4

Money Line: Falcons (+230) ; Eagles (-280)

Total: 47.5; Opened: 48.5

FPI favorite: Eagles by 5.7