Shepherd was injured when he ran into Darren Sproles after a play near the sideline during Sunday's practice at Lincoln Financial Field. An MRI on Monday confirmed he tore his ACL.
The sixth-round pick from Kansas saw action with the first unit at nickel cornerback. The Eagles are looking for a cornerback to take that starting spot after trading Brandon Boykin last week.
Linebacker Kiko Alonso remained out because of a concussion. Safety Jerome Couplin also is out after having an appendectomy last week.
Eagles rookie JaCorey Shepherd - torn ACL in right knee MRI Reveals. Shepherd was favorite to replace Brandon Boykin pic.twitter.com/tgxdKqaxWh— Jeff Skversky (@JeffSkversky) August 10, 2015
Information from The Associated Press was used in this post.