Mills is the first Eagles cornerback to win the award since Lito Sheppard in 2007.
Mills had a pick-6 in Philadelphia's 33-10 victory over the winless San Francisco 49ers this past Sunday.
The Eagles (7-1) have won six straight games.
Last week, quarterback Carson Wentz won the NFC Offensive Player of the Week award.
The Associated Press contributed to this report.
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