DeGuglielmo held the position for the past two seasons, after replacing longtime assistant Dante Scarnecchia.
In DeGuglielmo's first year on the job, the Patriots allowed just 21 sacks, fourth-fewest in the NFL, and the team won the Super Bowl. The offensive line, which suffered a string of injuries in 2015 and was playing with three rookies who totaled more than 50 percent of the snaps, contributed to that sack total's increasing to 38 this season.
DeGuglielmo previously served as assistant offensive line coach for the New York Giants (2004-08) and offensive line coach for the Miami Dolphins (2009-11) and New York Jets (2012).
NFL Network first reported the news of the Patriots' parting ways with DeGuglielmo.
ESPN's Adam Schefter contributed to this report.
Patriots part ways with OL coach DeGuglielmo
ESPN Patriots reporter Mike Reiss discusses reasons behind the Patriots decision to part ways with offensive line coach Dave DeGuglielmo.