Two others were taken to the hospital in critical and serious condition.
It happened around 4:30 a.m. Monday on Cottman Avenue near the Roosevelt Boulevard.
Police say two vehicles collided head-on.
The victims' identities have not been released.
All southbound lanes of the outer drive of the Roosevelt Boulevard were closed for approximately three and a half hours. Traffic began getting by the scene around 8 a.m.
Send a News Tip to Action News
Learn More About 6abc Apps