It happened around 2 a.m. on the eastbound lanes in Lower Saucon Township during the heavy rainfall.
The tangled mess then spilled over into the westbound lanes causing 78 to be closed in both directions for hours.
Authorities say the collision involved four tractor-trailers and another vehicle.
One tractor-trailer landed on top of the car. Another went down an embankment. Another split open leaving drums on the highway.
Hazmat crews responded to the scene, along with other emergency personnel.
No further details have been released on the person who was seriously injured.
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