The crash occurred around 9:30 a.m. Wednesday in the truck lanes of the highway Between interchanges 7 and 7A in Hamilton Township, not far from Trenton.
State police say 51 people were aboard the bus, which had severe front-end damage. The tractor-trailer also was damaged in the crash.
Authorities say 15 people suffered minor injuries.
Several bus passengers were seen along the side of the highway after the crash, including some who were being evaluated by emergency responders.
The cause of the crash is under investigation.
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