It happened around 6:30 a.m. Wednesday on northbound I-295 approaching Exit 22 which is Route 644/ Red Bank Avenue.
Police said the male victim was struck and left on the roadway.
The victim was pronounced dead at the scene.
Chopper 6 over the crash site showed vehicle debris on the highway.
All lanes of northbound I-295 are blocked near the scene. Drivers are advised to seek alternate routes.
Stay with 6abc.com and Action News as more information becomes available.