Pennsylvania State Police say it happened around 5:25 p.m. Saturday on northbound I-95 under the Ben Franklin Bridge.
Investigators say the biker lost control after hitting a pothole then a guardrail.
The 23-year-old victim from Collegeville, Pa. was taken to the hospital with severe head injuries.
Authorities say he later died of his injuries.
His identity has not been released.
Send a News Tip to Action News
Learn More About 6abc Apps