The crash happened after 7 a.m. Wednesday in the northbound lanes near the Girard Avenue exit.
Video from Chopper 6 HD showed a tractor-trailer which struck a construction sign and caught fire. The cab of the big rig showed fire damage and appeared to have lost one of its front wheels.
There were no immediate reports of injuries.
All northbound lanes were closed as firefighters and hazardous materials crews addressed diesel fuel spill that resulted from incident.
Northbound traffic was backed up for miles approaching the scene. Commuters were detoured off the highway onto the Vine Street Expressway for much of the morning.
The big rig was finally moved and the fuel spilled cleaned up by 11 a.m., and all northbound lanes were reopened.