The Turnpike eastbound was shut down between Downingtown (Exit 312) and Valley Forge (Exit 326) around 2:30 a.m.
Action News is told after the crash, the truck struck a bridge resulting in jugs of dish soap spilling out onto the Turnpike.
The eastbound lanes remained shut down until approximately 8:30 a.m. Tuesday..
The view from Chopper 6 showed the tractor trailer had been split apart.
Drivers were directed to take Route 100 southbound to the 30 Bypass eastbound to 202 northbound to avoid the crash site as crews worked to clear up the soap and debris.
There were no injuries reported.