The Blood Bank of Delmarva in New Castle County, Delaware, says they only have enough blood to last three days.
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Summer is already a slow time for blood donations.
But there is also a deficit in the supply because the pandemic has canceled most college and high school blood drives.
Those drives usually count for 25% of the blood collected during the school year.
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The blood bank is also asking people to be patient as they deal with a staff shortage.
"I promise you the person suffering from cancer will thank you in the future. That I can assure you of," said Tony Prado of Blood Bank of Delmarva.
He says there is high demand for anyone with type O blood.