The discovery was made just after midnight on the 1800 block of South 18th Street.
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Police said family members reported that they had not heard from the woman in some time, so officers were dispatched to the location for a wellness check.
When officers arrived they found the woman's body and called in the fire department to assist.
Burned body found in South Philadelphia home
Investigators said the 49-year-old woman had severe burns to more than 80 percent of her body.
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Police said it is undetermined at this time if it is a homicide.
The cause of death has not yet been determined.
The medical examiner's office will aid in the investigation.