It happened around 1:10 a.m. Monday at 12th and Spruce streets.
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Police said the fight originated inside the Cloud Factory Hookah Lounge, about an hour before closing time.
The altercation spilled onto the sidewalk and that's when investigators said a 28-year-old man was shot at least four times. He was taken to the hospital in critical condition.
A 25-year-old man was shot once in the leg, but police said he still managed to walk about half a mile to Pennsylvania Hospital for treatment.
Police said a third male was injured trying to break up the fight. He was hospitalized in stable condition.
Bullet holes could be seen in a mailbox on the street and the front window of the hookah lounge.
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Police found at least 12 shell casings on the sidewalk and street. Investigators also said they recovered a gun and made an arrest.
This was just the latest in a series of shootings across Philadelphia since Sunday afternoon. The violence included six people shot in Kensington and man found dead inside a South Philadelphia deli.
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