The centers will open at 78th and Mercury streets in the Eastwick section and at the Engine 12 firehouse on Main Street in Manayunk.
Both information centers will be open from 10 a.m. to 6 p.m. Thursday.
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Representatives from the Office of Emergency Management, 311, and CLIP will be present at the centers handing out Red Cross kits and supplies to residents impacted by the massive flooding that deluged streets and the surrounding homes.
Portions of Main Street in Manayunk flooded after Schuylkill River crests following Isaias
RELATED: Flooding in Manayunk affecting businesses and residents
More than 100 people were rescued in Eastwick alone.
Philadelphia residents evacuate after Eastwick neighborhood goes underwater
As cleanup continues, Philadelphia Fire Commissioner Adam Theil warned people to be careful, pointing out that the mud and the water could be contaminated.
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"You can actually smell the water, and some of the hydrocarbons that are in there, so please be careful over the next several days as folks return to their homes," said Theil. "If you smell gas, if you think your electrical system has been affected by flooding, please call 911."
READ ALSO: Tow truck driver helps rescue woman from flooded Belmont Avenue