Democrat Cherelle Parker is running against Republican David Oh for the position.
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Both candidates are former city council members, but only one of them will be the city's 100th mayor.
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No matter who wins, however, history will be made.
Oh would be the first Asian-American mayor and Parker would be the first woman to become mayor.
It's also been over 70 years since a Republican has won the mayoral race in the heavily Democratic city.
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Voters are casting their ballots for more than just the next mayor, such as electing city council, judges, the sheriff, and city controller.
Polls will be open from 7 a.m. until 8 p.m. on Tuesday.
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Those with mail-in ballots are asked to return them to one of the city's multiple drop box locations as soon as possible. They must be received by 8 p.m. on Election Day.
Meanwhile, Philadelphia City Commissioners say they have received hundreds of mail-in ballots that haven't been filled out correctly.
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Some are missing the secrecy envelope and signatures, and others have potentially incorrect dates.
Even Philadelphia Mayor Jim Kenney forgot to date his ballot but has since fixed the issue, and you can too.
To see if your ballot may have a potential problem and how you can correct it to have your vote counted, click here.
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