It happened around 1 a.m. on the westbound side of I-78 near Route 33 exit in Lower Saucon Township as stormy weather moved the region.
Authorities say a tractor-trailer hauling orange juice collided with another tractor-trailer.
Crews worked to clear away the containers of orange juice that spilled all over the roadway in order to reopen I-78 to traffic. It reopened around 6:30 a.m.
Both drivers were being treated for injuries.