Ikeem Johnson was shot on November 18 around 10:30 a.m. in the 7300 block of Rowland Avenue in the city's Mayfair section.
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Investigators are now searching for two men: 39-year-old Nushar Scott and 30-year-old Rasheem Trusty.
Both are considered armed and dangerous.
Scott is also wanted in connection with a homicide case from November 1, 2021, on the 900 block of South 4th Street.
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Anyone with information can submit an anonymous tip by calling 215-686-TIPS.
A $20,000 reward is being offered for information leading to an arrest.
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