Police said the 33-year-old woman, who is six months pregnant, was shot in the thigh on the 3500 block of North 18th Street.
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She was rushed to an area hospital and placed in critical condition.
The second victim, a 23-year-old man, was shot twice, once in the chest and once in the back.
He was taken to the hospital in extremely critical condition.
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The shooting happened Sunday afternoon, but no specific time has been given by police.
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Investigators did not find a weapon at the scene.
They are still searching for a suspect.
Police were also investigating a shooting Sunday at a West Philadelphia bus stop that injured a 14-year-old boy.
Anyone with information is asked to call police at 215-686-TIPS.