It happened just after 2 p.m. Thursday on the 700 block of E. Locust Avenue in the city's Germantown section.
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When officers arrived they found a man in his 40s and another man in his 30s suffering from gunshot wounds. Nearby, police say a 12-year-old boy was found shot just a short distance from the men.
All three victims were taken to an area hospital where they died.
At least 12 shots were fired at the scene, according to police.
Philly police provide update on deadly triple shooting
"We know that the two adult males were hit right at the top of the block, right by Crowson (Street), where they were found by police. It appears the juvenile was able to run towards his residence and was found a short distance away from the adults," said Deputy Commissioner of Investigations Frank Vanore.
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Police believe the shooters were driven to the scene and left in the same vehicle. Investigators are reviewing video to develop a description of the suspects.
As for the young victim, sources tell Action News he was celebrating a birthday Thursday.
He is now among at least 154 victims in the same age group who have been shot so far this year, including 27 who were shot and killed.
"Devastated to learn of the tragic killing of three people, including a 12-year-old child. No one should have their life and potential cut short by violence. Our communities deserve better. This senseless violence must stop," said Mayor Jim Kenney in a statement on Twitter.
Further details on the shooting were not immediately available.
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Anyone with information is asked to call police at 215-686-TIPS.
This is the second deadly triple shooting under investigation by police on Thursday.
Earlier in the day, police say a woman was killed and two men were injured after gunfire erupted near 21st Street and West Venango Street.
Police are still searching for the gunman in that shooting as well.
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