It happened around 12:54 a.m. Wednesday near The Met on the 800 block of North Broad Street.
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Police say more than 30 shots were fired during the gun battle between two groups of people.
A 45-year-old man is listed as critical after being shot in the eye. A second victim, a 42-year-old man, is stable after being shot in the thigh.
Police say the incident began as an argument at a nearby banquet location near the corner of Broad and Poplar streets, and ended with a white Mercedes riddled with bullets and the front window of the MET hit by gunfire.
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No other injuries were reported.
Anyone with information on the shooting is asked to call police at 215-686-TIPS.
RELATED: Check the 6abc Neighborhood Safety Tracker