The shooting happened around 2:16 p.m. Saturday at 19th and Market streets.
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Police say two men became involved in an altercation on a trolley platform.
During the altercation, one male pulled a handgun from his waistband and shot the other male several times.
The shooter fled the scene.
Medics performed CPR on the 64-year-old shooting victim and rushed him to the hospital, but he was pronounced dead at 2:50 p.m.
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The shooter is described as a Black male, 20 to 30 years old, medium build, last seen wearing a blue Polo shirt, a dark zip-up sweatshirt with a light-colored pattern and light-colored hood lining, dark pants, dark "slides "and a dark backpack.
A $20,000 reward is being offered for information leading to an arrest and conviction.
Anyone with information on the suspect is asked to call police at 215-686-3334/3335.